SIFT predicts whether an amino acid substitution affects protein function based on sequence homology and the physical properties of amino acids. SIFT can be applied to naturally occurring nonsynonymous polymorphisms and laboratory-induced missense mutations.

UPDATE on 3 March 2017
  • Reorganize website integrating SIFT 4G webpages with SIFT.
Genome Tools Single Protein Tools
SNV / SNP prediction

SIFT 4GSIFT For Genomes Predictions for human build 37, 38, and > 200 genomes 		protein sequence toolSIFT Sequence
      SIFT For Genomes (Online submission) (Beta) Predictions for some model organisms (e.g. human, mouse, worm, yeast). BLink toolSIFT BLink
       SIFT nonsynonymous single nucleotide variants (genome-scale) (human build 37) protein homologues toolSIFT Related Sequence
INDEL Prediction
1. genome coding variants filter tool Restrict indels to coding
 2. Classify coding indels (Insertion/Deletions). Human build 37 and 38) 		protein aligned sequences toolSIFT Aligned Sequences
Batch Tools
protein batch toolSIFT Batch Protein
SIFT dbSNP toolSIFT dbSNP 138 to be deprecated