# Rennell, D., et al. Systematic Mutation of bacteriophage T4
# lysozyme. J. Mol. Biol. 222:67-87.  Please reference this
# article if you publish using this data. 
#
# + means substitution does not alter phenotype
# - means substitution affects protein
# +- and -+ do not affect protein function as severely as "-"
# order of severity - > -+ > +- > +
#
# Questions about the format of this dataset? Email sift@fhcrc.org
#
N2G +
N2A +
N2L +
N2Q +
N2C +-
N2S +
N2Y +
N2F +
N2H +
N2P +
N2E +
N2R +
N2K +-
I3G +
I3A +
I3L +
I3Q +
I3C +-
I3S +
I3Y +
I3F +
I3H +
I3P +
I3E +-
I3R +-
I3K -+
F4G +
F4A +
F4L +
F4Q +
F4C +
F4S +
F4Y +
F4H +
F4P +
F4E +
F4R +
F4K +
E5G +
E5A +
E5L +
E5Q +
E5C +
E5S +
E5Y +
E5F +
E5H +
E5P +
E5R +
E5K +
M6G +-
M6A +
M6L +
M6Q +
M6C +-
M6S +
M6Y +-
M6F +-
M6H +-
M6P +-
M6E -
M6R - 
M6K -
L7G +
L7A +
L7Q +
L7C -+
L7S +
L7Y +
L7F +
L7H +-
L7P -
L7E -
L7R -
L7K -
R8G +
R8A +
R8L +
R8Q +
R8C +
R8S +
R8Y +
R8F +
R8H +
R8P +
R8E +
R8K +
I9G +
I9A +
I9L +
I9Q +
I9C +
I9S +
I9Y +
I9F +
I9H +
I9P +
I9E +
I9R +
I9K +
D10G -
D10A -
D10L +-
D10Q +-
D10C -
D10S -+
D10Y -
D10F - 
D10H -
D10P -
D10E +
D10R -
D10K -
E11G -
E11A -
E11L -
E11Q -
E11C -
E11S -
E11Y -
E11F -
E11H -
E11P -
E11R -
E11K -
G12A +
G12L +
G12Q +
G12C +-
G12S +
G12Y +-
G12F +
G12H +
G12P -
G12E +
G12R +
G12K -+
L13G +
L13A +
L13Q +
L13C +
L13S +
L13Y +
L13F +
L13H +
L13P +
L13E +
L13R +
L13K +
R14G +
R14A +
R14L +
R14Q +
R14C +
R14S +
R14Y +
R14F +
R14H +
R14P +
R14E +
R14K +
L15G +
L15A +
L15Q +
L15C +
L15S +
L15Y +
L15F +
L15H +
L15P +
L15E +
L15R +
L15K +-
K16G +
K16A +
K16L +
K16Q +
K16C +
K16S +
K16Y +
K16F +
K16H +
K16P +
K16E +
K16R +
I17G +-
I17A +
I17L +
I17Q +
I17C -+
I17S +-
I17Y +
I17F +
I17H +
I17P +
I17E -+
I17R -+
I17K -
Y18G +
Y18A +
Y18L +
Y18Q +
Y18C -+
Y18S +-
Y18F +
Y18H +
Y18P -+
Y18E +-
Y18R +-
Y18K -
K19G +
K19A +
K19L +
K19Q +
K19C +
K19S +
K19Y +
K19F +
K19H +
K19P +
K19E +
K19R +
D20G +-
D20A +
D20L -
D20Q -+
D20C +
D20S -+
D20Y -+
D20F -
D20H -+
D20P -+
D20E +
D20R -
D20K -
T21G +
T21A +
T21L +
T21Q +
T21C +
T21S +
T21Y +
T21F +
T21H +
T21P +
T21E +
T21R +
T21K +
E22G +
E22A +
E22L +
E22Q +
E22C +
E22S +
E22Y +
E22F +
E22H +
E22P +
E22R +
E22K +
G23A +
G23L +
G23Q +
G23C +-
G23S +
G23Y +
G23F +
G23H +
G23P +-
G23E +
G23R +
G23K +-
Y24G +
Y24A +
Y24L +
Y24Q +
Y24C +-
Y24S +
Y24F +
Y24H +
Y24P +-
Y24E +-
Y24R +
Y24K +-
Y25G +
Y25A +
Y25L +
Y25Q +
Y25C +
Y25S +
Y25F +
Y25H +
Y25P +
Y25E +
Y25R +
Y25K +
T26G +
T26A +
T26L -
T26Q -
T26C -+
T26S +
T26Y -+
T26F -+
T26H +-
T26P -+
T26E -
T26R -
T26K -
I27G +-
I27A +
I27L +-
I27Q +-
I27C +
I27S +
I27Y +-
I27F +-
I27H -+
I27P -
I27E -+
I27R -
I27K -
G28A +
G28L -
G28Q -
G28C -+
G28S +
G28Y -
G28F -
G28H -
G28P -
G28E -
G28R -
G28K -
I29G +
I29A +
I29L +
I29Q +
I29C +
I29S +
I29Y +
I29F +
I29H +
I29P +
I29E +
I29R +-
I29K -+
G30A +
G30L -
G30Q -
G30C -
G30S -+
G30Y -
G30F -
G30H -
G30P -
G30E -
G30R -
G30K -
H31G +-
H31A +
H31L +
H31Q +
H31C -+
H31S +
H31Y +
H31F +-
H31P -
H31E -+
H31R +
H31K -+
L32G +
L32A +
L32Q +
L32C +
L32S +
L32Y +
L32F +
L32H +
L32P +
L32E +-
L32R -+
L32K -+
L33G +
L33A +
L33Q +
L33C +
L33S +
L33Y +
L33F +
L33H +
L33P +
L33E +
L33R +
L33K +-
T34G +
T34A +
T34L +
T34Q +
T34C +
T34S +
T34Y +
T34F +
T34H +
T34P +
T34E +
T34R +
T34K +
K35G +
K35A +
K35L +
K35Q +
K35C +
K35S +
K35Y +
K35F +
K35H +
K35P +
K35E +
K35R +
S36G +
S36A +
S36L +
S36Q +
S36C +
S36Y +
S36F +
S36H +
S36P +
S36E +
S36R +
S36K +-
P37G +
P37A +
P37L +
P37Q +
P37C +
P37S +
P37Y +
P37F +
P37H +
P37E +
P37R +
P37K +-
S38G +
S38A +
S38L +
S38Q +
S38C +
S38Y +
S38F +
S38H +
S38P +
S38E +
S38R +
S38K +-
L39G +
L39A +
L39Q +
L39C +
L39S +
L39Y +
L39F +
L39H +
L39P +
L39E +
L39R +
L39K +-
N40G +
N40A +
N40L +
N40Q +
N40C +
N40S +
N40Y +
N40F +
N40H +
N40P +
N40E +
N40R +
N40K +
A41G +
A41L +
A41Q +
A41C +
A41S +
A41Y +
A41F +
A41H +
A41P +
A41E +
A41R +
A41K +
A42G +
A42L +
A42Q +
A42C +
A42S +
A42Y +
A42F +
A42H +
A42P +
A42E +-
A42R -+
A42K -+
K43G +
K43A +
K43L +
K43Q +
K43C +
K43S +
K43Y +
K43F +
K43H +
K43P +
K43E +
K43R +
S44G +
S44A +
S44L +
S44Q +
S44C +
S44Y +
S44F +
S44H +
S44P +
S44E +
S44R +
S44K +-
E45G +
E45A +
E45L +
E45Q +
E45C +-
E45S +
E45Y +
E45F +
E45H +
E45P +-
E45R +
E45K +-
L46G +-
L46A +
L46Q +-
L46C +-
L46S +-
L46Y -+
L46F +
L46H -+
L46P -+
L46E -
L46R -+
L46K -
D47G +
D47A +
D47L +
D47Q +
D47C +
D47S +
D47Y +
D47F +
D47H +
D47P +-
D47E +
D47R +
D47K +
K48G +
K48A +
K48L +
K48Q +
K48C +
K48S +
K48Y +
K48F +
K48H +
K48P +
K48E +
K48R +
A49G +
A49L +
A49Q +
A49C +
A49S +
A49Y +
A49F +
A49H +
A49P +
A49E +
A49R +
A49K +
I50G +
I50A +
I50L +
I50Q +
I50C +
I50S +
I50Y +
I50F +
I50H +
I50P -+
I50E +
I50R +
I50K +-
G51A +-
G51L +
G51Q +-
G51C -+
G51S +
G51Y +-
G51F +-
G51H +-
G51P +-
G51E +-
G51R +
G51K +-
R52G +
R52A +
R52L +
R52Q +
R52C +
R52S +
R52Y +
R52F +
R52H +
R52P +
R52E +
R52K +
N53G +
N53A +-
N53L +
N53Q +-
N53C -+
N53S +
N53Y +
N53F +-
N53H +-
N53P +-
N53E +-
N53R +-
N53K -+
C54G +
C54A +
C54L +
C54Q +
C54S +
C54Y +
C54F +
C54H +
C54P +
C54E +-
C54R +
C54K +
N55G +
N55A +
N55L +
N55Q +
N55C +
N55S +
N55Y +
N55F +
N55H +
N55P +
N55E +
N55R +
N55K +
G56A +
G56L +
G56Q +
G56C +
G56S +
G56Y +
G56F +
G56H +
G56P +
G56E +
G56R +
G56K +
V57G +
V57A +
V57L +
V57Q +
V57C +
V57S +
V57Y +
V57F +
V57H +
V57P +
V57E +
V57R +
V57K +
I58G -+
I58A +
I58L -+
I58Q -+
I58C +-
I58S +-
I58Y -+
I58F +
I58H -+
I58P +-
I58E -
I58R -
I58K -+
T59G +
T59A +-
T59L +-
T59Q +-
T59C -+
T59S +
T59Y +-
T59F -+
T59H +
T59P +-
T59E +-
T59R +
T59K -+
K60G +
K60A +
K60L +
K60Q +
K60C +
K60S +
K60Y +
K60F +
K60H +
K60P +
K60E +
K60R +
D61G +
D61A +
D61L +
D61Q +
D61C +-
D61S +
D61Y +
D61F +
D61H +
D61P +
D61E +
D61R +
D61K +-
E62G +
E62A +
E62L +
E62Q +
E62C +
E62S +
E62Y +
E62F +
E62H +
E62P -+
E62R -+
E62K -+
A63G +
A63L +
A63Q +
A63C +
A63S +
A63Y +
A63F +
A63H +-
A63P -
A63E -+
A63R -+
A63K -+
E64G +
E64A +
E64L +
E64Q +
E64C +
E64S +
E64Y +
E64F +
E64H +
E64P +
E64R +
E64K +
K65G +
K65A +
K65L +
K65Q +
K65C +
K65S +
K65Y +
K65F +
K65H +
K65P +
K65E +
K65R +
L66G -
L66A +-
L66Q +
L66C -+
L66S -+
L66Y +
L66F +
L66H +-
L66P -
L66E -
L66R +-
L66K -+
F67G +
F67A +
F67L +
F67Q +
F67C -+
F67S +
F67Y +
F67H +
F67P -
F67E +-
F67R +-
F67K -+
N68G +
N68A +
N68L +
N68Q +
N68C +
N68S +
N68Y +-
N68F +
N68H +
N68P +
N68E +
N68R +
N68K +
Q69G +
Q69A +
Q69L +
Q69C +
Q69S +
Q69Y +
Q69F +
Q69H +
Q69P +
Q69E +
Q69R +
Q69K +
D70G +
D70A +
D70L +
D70Q +
D70C -+
D70S +
D70Y +-
D70F -+
D70H +
D70P -+
D70E +
D70R -+
D70K -+
V71G +
V71A +
V71L +
V71Q +
V71C +
V71S +
V71Y +
V71F +
V71H +
V71P +-
V71E +
V71R +
V71K +
D72G +
D72A +
D72L +
D72Q +
D72C +
D72S +
D72Y +-
D72F +-
D72H +
D72P +
D72E +
D72R +
D72K +
A73G +
A73L +
A73Q +
A73C +
A73S +
A73Y +-
A73F +
A73H +
A73P +
A73E +
A73R +
A73K +
A74G +
A74L +
A74Q +
A74C +
A74S +
A74Y +
A74F +
A74H +
A74P +-
A74E +-
A74R +
A74K +
V75G +
V75A +
V75L +
V75Q +
V75C +-
V75S +
V75Y +
V75F +-
V75H +
V75P -+
V75E +-
V75R +
V75K +
R76G +
R76A +
R76L +
R76Q +
R76C +
R76S +
R76Y +
R76F +
R76H +
R76P +
R76E +
R76K +
G77A +
G77L +
G77Q +
G77C +
G77S +
G77Y +
G77F +
G77H +
G77P +
G77E +
G77R +
G77K +
I78G +-
I78A +
I78L +-
I78Q +-
I78C +-
I78S +
I78Y -+
I78F +-
I78H -+
I78P +-
I78E -
I78R -
I78K -+
L79G +
L79A +
L79Q +
L79C +-
L79S +
L79Y +
L79F +-
L79H +
L79P +
L79E +
L79R +
L79K +
R80G +
R80A +
R80L +
R80Q +
R80C +-
R80S +
R80Y +
R80F +-
R80H +
R80P +
R80E +
R80K +
N81G +
N81A +
N81L +
N81Q +
N81C +-
N81S +
N81Y +
N81F +-
N81H +
N81P +-
N81E +
N81R +
N81K +
A82G +
A82L +
A82Q +
A82C +-
A82S +
A82Y +
A82F +-
A82H +
A82P +
A82E +
A82R +
A82K +
K83G +
K83A +
K83L +
K83Q +
K83C +
K83S +
K83Y +
K83F +
K83H +
K83P +
K83E +
K83R +
L84G -+
L84A +
L84Q +-
L84C +
L84S +-
L84Y +-
L84F +
L84H +-
L84P -
L84E -
L84R -
L84K -
K85G +
K85A +
K85L +
K85Q +
K85C +
K85S +
K85Y +
K85F +
K85H +
K85P +-
K85E +
K85R +
P86G +
P86A +
P86L +
P86Q +
P86C +
P86S +
P86Y +
P86F +
P86H +
P86E +
P86R +
P86K +
V87G +
V87A +
V87L +
V87Q +-
V87C -+
V87S +
V87Y +
V87F +-
V87H +
V87P +
V87E -
V87R -+
V87K -+
Y88G +
Y88A +
Y88L +
Y88Q +
Y88C +
Y88S +-
Y88F +
Y88H +
Y88P -
Y88E +-
Y88R +
Y88K -
D89G +
D89A +-
D89L +
D89Q +
D89C +-
D89S +-
D89Y +
D89F +-
D89H +
D89P +
D89E +-
D89R +
D89K +-
S90G +
S90A +
S90L +
S90Q +
S90C +
S90Y +
S90F +
S90H +
S90P +
S90E +
S90R +
S90K +
L91G +
L91A +
L91Q +
L91C +
L91S +-
L91Y +-
L91F +
L91H +
L91P -
L91E -+
L91R -
L91K -+
D92G +
D92A +
D92L +
D92Q +
D92C +
D92S +
D92Y +
D92F +
D92H +
D92P +
D92E +
D92R +
D92K -+
A93G +
A93L +
A93Q +
A93C +
A93S +
A93Y +
A93F +
A93H +
A93P +
A93E +
A93R +
A93K +
V94G +
V94A +-
V94L +
V94Q +
V94C -+
V94S +
V94Y +
V94F +-
V94H +-
V94P +
V94E +-
V94R +-
V94K +-
R95G +
R95A +-
R95L +
R95Q +
R95C -
R95S +-
R95Y -
R95F -
R95H -+
R95P -+
R95E -+
R95K +-
R96G +
R96A +-
R96L +
R96Q +
R96C -+
R96S +
R96Y +
R96F +-
R96H +-
R96P -+
R96E +-
R96K +-
C97G +
C97A +
C97L +
C97Q +
C97S +
C97Y +
C97F +
C97H +-
C97P +
C97E +
C97R +
C97K +-
A98G +
A98L -+
A98Q -+
A98C +-
A98S +
A98Y -
A98F -
A98H -
A98P +-
A98E -
A98R -
A98K -+
L99G -+
L99A +
L99Q +
L99C +-
L99S +-
L99Y +
L99F +
L99H +
L99P -
L99E +-
L99R -
L99K +-
I100G +
I100A +
I100L +
I100Q +
I100C +-
I100S +
I100Y +
I100F +
I100H +
I100P -
I100E +
I100R +
I100K +-
N101G +
N101A +
N101L +-
N101Q +-
N101C +-
N101S +
N101Y +-
N101F +-
N101H +-
N101P -
N101E -+
N101R -
N101K -+
M102G +-
M102A +
M102L +
M102Q +
M102C +-
M102S +
M102Y -
M102F +-
M102H +-
M102P -
M102E -
M102R -
M102K -+
V103G +
V103A +
V103L +
V103Q +
V103C +-
V103S +
V103Y +
V103F +-
V103H +
V103P -
V103E +-
V103R +-
V103K -+
F104G +-
F104A +
F104L +-
F104Q +-
F104C +-
F104S +-
F104Y +
F104H +-
F104P -
F104E -+
F104R -
F104K -+
Q105G +
Q105A +
Q105L +
Q105C +-
Q105S +
Q105Y -
Q105F -
Q105H +
Q105P -
Q105E +
Q105R -
Q105K -+
M106G +
M106A +
M106L +
M106Q +
M106C +-
M106S +
M106Y -+
M106F +
M106H +
M106P -
M106E +-
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